
Mesoblast Limited
NASDAQ•MESO
CEO: Dr. Silviu Itescu FACP, FACRA, FRACP, MBBS (Hons)
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2010-01-20
Mesoblast Limited engages in the development of regenerative medicine products in Australia, the United States, Singapore, and Switzerland. Its proprietary regenerative medicine technology platform is based on specialized cells known as mesenchymal lineage cells. The company offers Remestemcel-L that is in Phase III clinical trials for the treatment of systemic inflammatory diseases, including steroid refractory acute graft versus host disease and biologic refractory inflammatory bowel disease, as well as Crohn's disease; and Remestemcel-L, which is in Phase III clinical trials to treat chronic heart failure and chronic low back pain due to degenerative disc disease. It is also developing MPC-300-IV to treat biologic refractory rheumatoid arthritis diabetic nephropathy. It has strategic partnerships with Tasly Pharmaceutical Group to offer MPC-150-IM for the treatment or prevention of chronic heart failure and MPC-25-IC for the treatment or prevention of acute myocardial infarction; JCR Pharmaceuticals Co. Ltd. to treat wound healing in patients with epidermolysis bullosa and for the treatment of neonatal hypoxic ischemic encephalopathy; and Grünenthal to develops and commercializes cell therapy for the treatment of chronic low back pain. The company was incorporated in 2004 and is headquartered in Melbourne, Australia.
Contact Information
Market Cap
$2.24B
P/E (TTM)
-22.0
38.2
Dividend Yield
--
52W High
$21.50
52W Low
$9.61
52W Range
Rank60Top 89.2%
2.1
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 2.1 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025
Financial Dashboard
Q4 2025 Data
Revenue
$7.02M+458.55%
4-Quarter Trend
EPS
-$0.21-16.00%
4-Quarter Trend
FCF
-$14.94M+17268.02%
4-Quarter Trend
2025 Annual Earnings Highlights
Key Highlights
Total Revenue Jumps 191% Total revenues reached $17.2M in FY2025, up 191% from $5.9M in FY2024, driven by Ryoncil launch activities.
Ryoncil Commercial Launch Success Recognized $11.3M in net product sales from Ryoncil launch starting March 2025; 25 transplant centers onboarded.
Strengthened Cash Position Cash reserves increased to $161.6M by June 30, 2025, supported by $161.0M capital raise completed in January 2025.
R&D Expenses Decrease R&D expenses fell 12% to $34.8M in FY2025, primarily due to reversal of pre-launch inventory provision upon approval.
Risk Factors
Continued Operating Losses Expected Incurred accumulated losses of $1.01B since inception; anticipates substantial operating losses for the foreseeable future.
Commercialization Success Dependence Business success substantially dependent on Ryoncil sales until next product candidate achieves regulatory approval and market acceptance.
Manufacturing Supply Chain Reliance Relies on contract manufacturer Lonza for commercial scale production; disruptions could severely affect operations and costs.
Regulatory Hurdles Remain High Novel cell therapy development faces high failure rates, complex regulatory requirements, and potential clinical delays impacting timelines.
Outlook
Advance Ryoncil Label Expansion Plans pivotal controlled study for Ryoncil in high-risk adult SR-aGVHD patients, targeting label extension opportunities.
Finalizing Debt Refinancing Plans In advanced stages of finalizing plans to refinance existing debt arrangements within the next twelve months to address repayments.
Progress Revascor Development Seeking accelerated approval pathway for Revascor (HFrEF); alignment achieved with FDA on CMC and trial design components.
Focus on Core Strategic Imperatives Strategy centers on optimizing disruptive technology platform, prioritizing late-stage portfolio, and strengthening intellectual property estate.
Peer Comparison
Revenue (TTM)
SRPT$2.41B
TVTX$435.83M
$316.64M
Gross Margin (Latest Quarter)
475.5%
TVTX99.0%
94.2%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| COGT | $5.92B | -15.1 | -126.2% | 14.2% |
| CELC | $4.95B | -29.4 | -179.0% | 67.3% |
| LQDA | $3.30B | -26.9 | -296.8% | 72.2% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
64.5%
Strong Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention
Research & Insights
Next earnings:Feb 25, 2026
EPS:-
|Revenue:-
Reports
All Years
Form 20-F - FY 2025
Period End: Jun 30, 2025|Filed: Aug 29, 2025|Revenue: $17.20M+191.4%|EPS: $-0.84+5.3%MissForm 20-F - FY 2024
Period End: Jun 30, 2024|Filed: Aug 29, 2024|Revenue: $5.90M-21.3%|EPS: $-0.89+8.9%MissForm 20-F - FY 2023
Period End: Jun 30, 2023|Filed: Aug 31, 2023|Revenue: $7.50M-26.5%|EPS: $-0.98+24.8%MeetForm 20-F - FY 2022
Period End: Jun 30, 2022|Filed: Aug 31, 2022|Revenue: $10.21M+37.0%|EPS: $-1.30+18.8%MissForm 20-F - FY 2021
Period End: Jun 30, 2021|Filed: Aug 31, 2021|Revenue: $7.46M-76.8%|EPS: $-1.60-6.7%Miss