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Ironwood Pharmaceuticals, Inc.

NASDAQ•IRWD
CEO: Mr. Thomas A. McCourt
Sector: Healthcare
Industry: Drug Manufacturers - Specialty & Generic
Listing Date: 2010-02-03
Ironwood Pharmaceuticals, Inc., a healthcare company, focuses on the development and commercialization of gastrointestinal (GI) products. It markets linaclotide, a guanylate cyclase type-C (GC-C) agonist for the treatment of adults suffering from irritable bowel syndrome with constipation or chronic idiopathic constipation under the LINZESS name in the United States, Mexico, Japan, Saudi Arabia, and China, as well as under the CONSTELLA name in the Canada and European countries. The company is also developing IW-3300, a GC-C agonist for the treatment of visceral pain conditions, including interstitial cystitis/bladder pain syndrome and endometriosis; Apraglutide, a next-generation, long-acting synthetic peptide analog of glucagon-like peptide-2, as a differentiated therapeutic for rare diseases, including short bowel syndrome dependent on parenteral support and acute graft versus host disease; and CNP-104, an immune nanoparticle for the treatment of primary biliary cholangitis. The company has strategic partnerships with AbbVie Inc., AstraZeneca AB, and Astellas Pharma Inc. for the development and commercialization of linaclotide. The company was formerly known as Microbia, Inc. and changed its name to Ironwood Pharmaceuticals, Inc. in April 2008. Ironwood Pharmaceuticals, Inc. was incorporated in 1998 and is headquartered in Boston, Massachusetts.
Contact Information
100 Summer Street, Suite 2300, Boston, MA, 02110, United States
617-621-7722
www.ironwoodpharma.com
Market Cap
$549.51M
P/E (TTM)
22.8
14.3
Dividend Yield
--
52W High
$5.78
52W Low
$0.53
52W Range
54%
Rank46Top 59.5%
3.5
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 3.5 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025

Financial Dashboard

Q4 2025 Data

Revenue

$47.71M+0.00%
4-Quarter Trend

EPS

-$0.01+0.00%
4-Quarter Trend

FCF

$74.58M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Net Income Jumps Significantly Net income reached $24.0M in 2025 versus $0.9M in 2024, driven by lower operating expenses.
Cash Flow Improves Substantially Cash from operations totaled $127.0M in 2025, increasing $23.5M from prior year levels.
LINZESS Revenue Decline Collaborative revenue fell $55.3M to $296.2M, driven by net price and inventory fluctuations.
R&D Spending Reduced Total R&D expenses decreased $16.3M to $95.1M, reflecting program prioritization efforts.

Risk Factors

LINZESS Revenue Dependency Highly dependent on LINZESS U.S. commercial success; revenues constitute significant portion of total revenue.
Apraglutide Regulatory Delay Apraglutide requires confirmatory Phase III trial (STARS-2) needed for NDA submission; site initiations Q2 2026.
Pricing Policy Uncertainty Subject to U.S. pricing uncertainty; LINZESS MFP set to $136 effective January 1, 2027.
High Indebtedness Level Total indebtedness reached $585.0M as of December 31, 2025, limiting financial flexibility.

Outlook

Advance Apraglutide Trial Plan to initiate confirmatory STARS-2 Phase III trial for apraglutide in second quarter 2026.
Maximize LINZESS Potential Strategy focuses on leveraging U.S. commercial capabilities with AbbVie to expand LINZESS.
Sustained Profit Focus Executing strategy to deliver sustained profits and cash flow through disciplined operations.
Pipeline Investment Continues Continue investing in linaclotide profile enhancement and advancing pipeline programs internally.

Peer Comparison

Revenue (TTM)

NEO stock ticker logoNEO
$727.33M
+10.1%
IRWD stock ticker logoIRWD
$296.15M
-15.7%
CGC stock ticker logoCGC
$278.39M
+0.6%

Gross Margin (Latest Quarter)

RNAC stock ticker logoRNAC
100.0%
-2831.2pp
IRWD stock ticker logoIRWD
99.0%
+32.6pp
FENC stock ticker logoFENC
94.7%
+14.2pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
IRWD$549.51M22.8-8.2%150.6%
CGC$524.81M-1.5-52.9%23.1%
NPCE$474.37M-21.5-105.7%67.1%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
5.1%
Steady Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
75%
Volatile Cash Flow

Deep Research

Next earnings:Apr 30, 2026
|
EPS:$0.25
|
Revenue:$92.11M
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement
LTM
No Data