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Sana Biotechnology, Inc.

NASDAQ•SANA
CEO: Dr. Steven D. Harr M.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2021-02-04
Sana Biotechnology, Inc., a biotechnology company, focuses on utilizing engineered cells as medicines. It develops ex vivo and in vivo cell engineering platforms for various therapeutic areas with unmet treatment needs, including oncology, diabetes, central nervous system disorders, B-cell-mediated autoimmune, and others. The company's product candidates include SC291 that is used as allogeneic cell therapies for hematologic malignancies; ARDENT for a potential treatment for non-Hodgkin's lymphoma, and chronic lymphoblastic leukemia; GLEAM, to treat multiple autoimmune disorders that involve production of autoimmune antibodies, including lupus nephritis, extrarenal lupus, antineutrophil cytoplasmic antibody -associated vasculitis, and others. It is developing SC262 to treat patients with relapsed and/or refractory B-cell malignancies; SC255 for multiple myeloma treatment; SC379, a therapy for patients with certain central nervous system disorders healthy allogeneic glial progenitor cells; SC451, a product candidate to treat diabetes, with an initial focus on type 1 diabetes mellitus; and UP421 that reduces long-term exogenous insulin dependence. The company has an option and license agreement with Beam Therapeutics Inc. for use of Beam's proprietary CRISPR Cas12b nuclease editing technology to research, develop, and commercialize engineered cell therapy products; and a license agreement with Harvard College to access certain intellectual property for the development of hypoimmune-modified cells. The company was formerly known as FD Therapeutics, Inc. and changed its name to Sana Biotechnology, Inc. in September 2018. Sana Biotechnology, Inc. was incorporated in 2018 and is headquartered in Seattle, Washington.
Contact Information
188 East Blaine Street, Suite 400, Seattle, WA, 98102, United States
206-701-7914
www.sana.com
Market Cap
$896.67M
P/E (TTM)
-3.5
17.9
Dividend Yield
--
52W High
$6.55
52W Low
$1.26
52W Range
40%
Rank52Top 73.5%
2.9
F-Score
Modified Piotroski Analysis
Based on 7-year fundamentals
Weak • 2.9 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2019-2025

Financial Dashboard

Q4 2025 Data

Revenue

$0.00+0.00%
4-Quarter Trend

EPS

-$0.21+0.00%
4-Quarter Trend

FCF

-$33.51M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Net Loss Reduction Net loss decreased to 244.2M USD in 2025 from 266.8M USD in 2024, reflecting disciplined cost management and strategic portfolio prioritization.
R&D Expense Decline Research and development expenses fell to 132.0M USD in 2025 from 215.7M USD in 2024, driven by strategic focus on core programs.
Clinical Program Advancement Achieved 12-month safety and efficacy data for UP421 in T1D and advanced SG293 to clinical testing for B cell cancers this year.

Risk Factors

Going Concern Uncertainty Management identified substantial doubt regarding ability to continue as a going concern, requiring additional capital to fund future operations and business plans.
Capital Funding Requirements Cash and marketable securities of 138.4M USD are insufficient for long-term operations, necessitating future financing to avoid program delays or potential termination.
Regulatory Approval Challenges Novel cell engineering platforms face complex, unpredictable regulatory pathways, potentially delaying or preventing approval of SC451 and SG293 product candidates in development.
Manufacturing Complexity Risks Complex manufacturing processes for biologics pose risks of production delays, contamination, or failure to scale, impacting clinical and commercial supply chain reliability.

Outlook

Advance Lead Programs Prioritizing development of SC451 for type 1 diabetes and SG293 for B cell cancers, targeting initial clinical data generation as early as this year.
Manufacturing Infrastructure Investment Investing in process development, analytical capabilities, and GMP facilities to support scalable manufacturing and meet future pipeline supply needs for clinical programs.
Strategic Capital Allocation Focusing resources on high-probability programs while seeking additional financing to extend cash runway and support ongoing clinical development and research efforts.

Peer Comparison

Revenue (TTM)

PHAT stock ticker logoPHAT
$175.11M
+216.9%
SNDX stock ticker logoSNDX
$172.35M
+627.8%
XNCR stock ticker logoXNCR
$125.58M
+4.0%

Gross Margin (Latest Quarter)

SNDX stock ticker logoSNDX
102.3%
-13.9pp
DNTH stock ticker logoDNTH
100.0%
+0.0pp
ATAI stock ticker logoATAI
100.0%
+0.0pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
PRAX$6.21B-21.8-58.7%0.0%
DNTH$2.82B0.00.0%0.3%
WVE$2.45B-11.5-85.0%2.8%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
N/M
Revenue Volatile
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Deep Research

Next earnings:Mar 16, 2026
|
EPS:-$0.12
|
Revenue:-
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement
LTM
No Data