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Seres Therapeutics, Inc.

Seres Therapeutics, Inc.

NASDAQ•MCRB
CEO: Mr. Eric D. Shaff M.B.A.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2015-06-26
Seres Therapeutics, Inc., a microbiome therapeutics company, develop microbiome therapeutics to treat the modulation of the colonic microbiome. It develops a novel class of biological drugs that are designed to treat by modulating the microbiome to restore health by repairing the function of a disrupted microbiome to a non-disease state. The company's lead product candidate is VOWST, an oral microbiome therapeutic that has completed Phase III clinical trial for the treatment of recurrent Clostridioides difficile infection. Its product pipeline also includes SER-155, an investigational oral fermented microbiome therapeutic which is in Phase 1b clinical trials for the treatment of gastrointestinal infections, bacteremia, and graft versus host disease in immunocompromised patients including patients receiving allogeneic hematopoietic stem cell transplantation. In addition, the company engages in the development of SER-287 which is in Phase 2b and SER-301 that is in Phase 1b to treat ulcerative colitis. Further, it has license Agreement with NHSc Rx License GmbH for the therapeutic products based on the microbiome technology, which includes VOWST product candidate, which is developed for the treatment of CDI and recurrent CDI; and collaboration license agreement with Société des Produits Nestlé S.A. (Nestlé) for the development and commercialization of certain product candidates for the treatment and management of CDI and inflammatory bowel disease including UC and Crohn's disease. The company was formerly known as Seres Health, Inc. and changed its name to Seres Therapeutics, Inc. in May 2015. Seres Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts.
Contact Information
101 Cambridgepark Drive, Cambridge, MA, 02140, United States
617-945-9626
www.serestherapeutics.com
Market Cap
$144.38M
P/E (TTM)
25.9
38.2
Dividend Yield
--
52W High
$29.98
52W Low
$6.53
52W Range
40%
Rank56Top 81.7%
2.5
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 2.5 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025

Financial Dashboard

Q3 2025 Data

Revenue

$351.00K+0.00%
4-Quarter Trend

EPS

$0.94-91.92%
4-Quarter Trend

FCF

$2.20M-106.31%
4-Quarter Trend

2025 Q3 Earnings Highlights

Key Highlights

Continuing Operations Profitability Nine months net income from continuing operations reached $21.0M, reversing prior period loss of $(110.1)M.
VOWST Transaction Income Realized Other income net totaled $95.6M income, driven by installment payments and TSA reimbursement from Nestlé.
Cash Position Strengthened Cash and cash equivalents grew to $47.6M by September 30, 2025, supporting near-term operations.
Operating Loss Significantly Narrows Loss from operations decreased $17.9M to $(74.6)M for nine months due to reduced R&D spending.

Risk Factors

Critical Additional Funding Required Additional capital needed to fund SER-155 Phase 2 study; failure risks cost reductions or winding down.
Clinical Stage Development Risks Product candidates face risky, lengthy, expensive clinical development with uncertain regulatory approval outcomes.
Going Concern Doubt Remains Substantial doubt exists regarding ability to continue as going concern beyond Q2 2026 cash runway.
Key Executive Transition Uncertainty Recent CEO resignation and appointment of Co-CEOs introduces management uncertainty and operational disruption risks.

Outlook

Finalize SER-155 Phase 2 Study Progressing startup activities for SER-155 Phase 2 study, incorporating recent FDA feedback for protocol finalization.
Pipeline Development Focus Investment focus remains on advancing SER-155 and other wholly-owned cultivated live biotherapeutic candidates.
Workforce Reduction Implemented Implemented cost reduction actions, including 25% workforce reduction in September 2025, incurring $1.0M restructuring costs.
Evaluating Strategic Deal Structures Evaluating potential deal structures to leverage VOWST success and support broader portfolio development efforts.

Peer Comparison

Revenue (TTM)

Innate Pharma S.A.IPHA
$36.93M
-61.2%
Tonix Pharmaceuticals Holding Corp.TNXP
$10.30M
-145.5%
Nkarta, Inc.NKTX
$9.03M
-14.3%

Gross Margin (Latest Quarter)

Applied Therapeutics, Inc.APLT
100.0%
+0.0pp
Fate Therapeutics, Inc.FATE
100.0%
+0.0pp
Tonix Pharmaceuticals Holding Corp.TNXP
58.5%
+13.6pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
FBRX$418.27M-11.5-75.6%0.0%
ACHV$310.29M-3.9-196.7%19.1%
MIST$174.60M-2.3-2372.7%65.2%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-61.1%
Growth Under Pressure
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
50%
Cash Flow Needs Attention

Research & Insights

Next earnings:Mar 12, 2026
|
EPS:-$2.39
|
Revenue:-
Reports
All Years
  • Form 10-Q - Q3 2025

    Period End: Sep 30, 2025|Filed: Nov 5, 2025|
    Revenue: $351.00K+0.0%
    |
    EPS: $0.94-91.9%
    Meet
  • Form 10-Q - Q2 2025

    Period End: Jun 30, 2025|Filed: Aug 6, 2025|
    Revenue: $0.00+0.0%
    |
    EPS: $-2.27-47.7%
    N/A
  • Form 10-Q - Q1 2025

    Period End: Mar 31, 2025|Filed: May 7, 2025|
    Revenue: $0.00+0.0%
    |
    EPS: $3.76-1492.6%
    N/A
  • Form 10-K - FY 2024

    Period End: Dec 31, 2024|Filed: Mar 13, 2025|
    Revenue: $0.00+0.0%
    |
    EPS: $-18.86-6.2%
    N/A
  • Form 10-Q - Q3 2024

    Period End: Sep 30, 2024|Filed: Nov 13, 2024|
    Revenue: $0.00-100.0%
    |
    EPS: $11.60-3235.1%
    N/A
  • Form 10-Q - Q2 2024

    Period End: Jun 30, 2024|Filed: Aug 13, 2024|
    Revenue: $0.00-100.0%
    |
    EPS: $-4.34-1305.6%
    N/A
  • Form 10-Q - Q1 2024

    Period End: Mar 31, 2024|Filed: May 8, 2024|
    Revenue: $0.00-100.0%
    |
    EPS: $-0.27-52.6%
    N/A
  • Form 10-K - FY 2023

    Period End: Dec 31, 2023|Filed: Mar 5, 2024|
    Revenue: $126.33M+1672.2%
    |
    EPS: $-0.89+61.5%
    Beat