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Castle Biosciences, Inc.

Castle Biosciences, Inc.

NASDAQ•CSTL
CEO: Mr. Derek J. Maetzold
Sector: Healthcare
Industry: Medical - Diagnostics & Research
Listing Date: 2019-07-25
Castle Biosciences, Inc., a molecular diagnostics company, provides testing solutions for the diagnosis and treatment of dermatologic cancers, Barrett's esophagus, uveal melanoma, and mental health conditions. It offers DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test to identify the risk of metastasis for patients diagnosed with invasive cutaneous melanoma; DecisionDx-SCC, a proprietary risk stratification GEP test for patients with cutaneous squamous cell carcinoma; MyPath Melanoma, a test used for patients with difficult-to-diagnose melanocytic lesions; and TissueCypher, a spatial omics test to predict future development of high-grade dysplasia and/or esophageal cancer in patients with non-dysplastic, indefinite dysplasia, or low-grade dysplasia Barrett's esophagus. In addition, the company provides DecisionDx-UM test, a proprietary risk stratification GEP test that predicts the risk of metastasis for patients with uveal melanoma; and IDgenetix, a pharmacogenomic test that helps guide drug treatment for major depressive disorder, schizophrenia, bipolar disorder, anxiety disorders, social phobia, obsessive-compulsive personality disorder, post-traumatic stress disorder, and attention deficit hyperactivity disorder. It offers its products to skin cancer, gastroenterology, and mental health markets. The company was incorporated in 2007 and is headquartered in Friendswood, Texas.
Contact Information
505 South Friendswood Drive, Suite 401, Friendswood, TX, 77546, United States
866-788-9007
castlebiosciences.com
Market Cap
$1.11B
P/E (TTM)
-116.3
25.7
Dividend Yield
--
52W High
$40.61
52W Low
$14.59
52W Range
90%
Rank67Top 91.5%
1.8
F-Score
Modified Piotroski Analysis
Based on 8-year fundamentals
Weak • 1.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2017-2024

Financial Dashboard

Q3 2025 Data

Revenue

$83.04M-3.19%
4-Quarter Trend

EPS

-$0.02-121.10%
4-Quarter Trend

FCF

$7.80M-54.03%
4-Quarter Trend

2025 Q3 Earnings Highlights

Key Highlights

Revenue Growth Maintained Net revenues reached $257.2M USD, marking a 4.7% increase for the nine months ended September 30, 2025.
Non-Derm Revenue Surge Non-dermatologic revenue increased $36.9M USD, driven by 90.5% TissueCypher volume growth during nine months.
Test Volume Adoption Rises Total test reports volume increased 8.1% to 77.8M units for the nine months ended September 30, 2025.
Asset Base Expansion Total assets grew to $562.8M USD as of September 30, 2025, up from $531.2M USD year-end 2024.

Risk Factors

Profitability Deterioration Net loss reached $(21.8M) USD for nine months, a $(30.5M) deterioration from prior year net income.
Gross Margin Compression Gross margin percentage fell to 66.8% USD, down 12.5% due to lower DecisionDx-SCC average selling price.
Dermatologic Revenue Decline Dermatologic revenue dropped $25.4M USD, primarily due to loss of Medicare coverage for DecisionDx-SCC test.
Operating Expense Increase Total operating expenses increased 22.8% to $296.2M USD, heavily impacted by $25.8M amortization increase.

Outlook

New Test Launch Planned Plan to launch sixth MAAA test in November 2025, expecting new revenue stream to offset SCC decline.
Continued R&D Investment Expect R&D expenses to increase as company invests in pipeline development and new product initiatives.
Headquarters Capital Spend Incurred $20.8M USD capital spend on headquarters construction, funded by 2024 Term Loan proceeds.
Regulatory Designation Secured DecisionDx-Melanoma received FDA Breakthrough Device designation, potentially expediting future regulatory review.

Peer Comparison

Revenue (TTM)

Myriad Genetics, Inc.MYGN
$832.90M
+3.8%
SNDL Inc.SNDL
$680.39M
+4.4%
CareDx, IncCDNA
$358.00M
+14.5%

Gross Margin (Latest Quarter)

SI-BONE, Inc.SIBN
79.8%
+0.8pp
Castle Biosciences, Inc.CSTL
76.6%
-3.6pp
Myriad Genetics, Inc.MYGN
71.2%
+1.7pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
CSTL$1.11B-116.3-2.1%6.9%
CDNA$1.01B16.917.4%4.9%
FLGT$836.76M-19.5-3.8%0.0%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-1.3%
Flat Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
75%
Volatile Cash Flow

Research & Insights

Next earnings:Feb 26, 2026
|
EPS:-$0.17
|
Revenue:-
Reports
All Years
  • Form 10-Q - Q3 2025

    Period End: Sep 30, 2025|Filed: Nov 3, 2025|
    Revenue: $83.04M-3.2%
    |
    EPS: $-0.02-121.1%
    Beat
  • Form 10-Q - Q2 2025

    Period End: Jun 30, 2025|Filed: Aug 4, 2025|
    Revenue: $86.19M-0.9%
    |
    EPS: $0.16-50.0%
    Beat
  • Form 10-Q - Q1 2025

    Period End: Mar 31, 2025|Filed: May 5, 2025|
    Revenue: $87.99M+20.6%
    |
    EPS: $-0.90+876.1%
    Miss
  • Form 10-K - FY 2024

    Period End: Dec 31, 2024|Filed: Feb 27, 2025|
    Revenue: $332.07M+51.1%
    |
    EPS: $0.66+130.8%
    Beat
  • Form 10-Q - Q3 2024

    Period End: Sep 30, 2024|Filed: Nov 4, 2024|
    Revenue: $85.78M+39.5%
    |
    EPS: $0.08-131.3%
    Beat
  • Form 10-Q - Q2 2024

    Period End: Jun 30, 2024|Filed: Aug 5, 2024|
    Revenue: $87.00M+73.5%
    |
    EPS: $0.32-145.7%
    Beat
  • Form 10-Q - Q1 2024

    Period End: Mar 31, 2024|Filed: May 2, 2024|
    Revenue: $72.97M+73.6%
    |
    EPS: $-0.09-91.6%
    Beat
  • Form 10-K - FY 2023

    Period End: Dec 31, 2023|Filed: Feb 28, 2024|
    Revenue: $219.79M+60.4%
    |
    EPS: $-2.14+17.1%
    Miss