Nurix Therapeutics, Inc.
NASDAQ•NRIX
CEO: Dr. Arthur T. Sands M.D., Ph.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2020-07-24
Nurix Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the discovery, development, and commercialization of small molecule and cell therapies for the treatment of cancer, inflammatory conditions, and other diseases. The company develops NX-2127, an orally bioavailable Bruton's tyrosine kinase (BTK) degrader for the treatment of relapsed or refractory B-cell malignancies; NX-5948, an orally bioavailable BTK degrader for the treatment of relapsed or refractory B-cell malignancies and autoimmune diseases; and NX-1607, an orally bioavailable Casitas B-lineage lymphoma proto-oncogene-B (CBL-B) inhibitor for immuno-oncology indications. It is also developing NX-0479/GS-6791, a IRAK4 degrader for the treatment of rheumatoid arthritis and other inflammatory diseases. The company has a strategic collaboration agreement with Gilead Sciences, Inc., Sanofi S.A., and Seagen Inc. co-development and co-commercialization for multiple drug candidates. The company was formerly known as Nurix Inc. and changed its name to Nurix Therapeutics, Inc. in October 2018. Nurix Therapeutics, Inc. was incorporated in 2009 and is headquartered in San Francisco, California.
Contact Information
Market Cap
$1.25B
P/E (TTM)
-5.2
17.7
Dividend Yield
--
52W High
$22.50
52W Low
$8.18
52W Range
Rank52Top 73.5%
2.9
F-Score
Modified Piotroski Analysis
Based on 7-year fundamentals
Weak • 2.9 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2019-2025
Financial Dashboard
Q4 2025 Data
Revenue
$13.58M+2.21%
4-Quarter Trend
EPS
-$0.82+9.33%
4-Quarter Trend
FCF
-$72.96M+43.47%
4-Quarter Trend
2025 Annual Earnings Highlights
Key Highlights
Revenue Driven By License Deal Total revenue reached $84.0M, up $29.4M, driven by $30.0M license revenue recognized from Sanofi extensions.
Increased R&D Investment Research and development expenses totaled $316.9M, reflecting a $95.3M increase year-over-year to accelerate clinical trials.
Strong Liquidity Position Cash, cash equivalents, and marketable securities totaled $592.9M as of November 30, 2025, funding operations for 12 months.
Lead Drug Advancement Bexobrutideg Phase 2 enrollment ongoing; planning suite of additional trials for 2026 registration support.
Risk Factors
Continued Operating Losses Net loss was $(264.5M) for 2025; expects incurring losses for several future years, never achieving profitability.
Substantial Capital Needs Requires substantial additional funding to support operations; inability to raise capital may delay or terminate programs.
Early Stage Clinical Risk Lead candidates (bexobrutideg, zelebrudomide, NX-1607) are in early clinical stages; failure materially harms business.
Reliance on Third-Party Manufacturing Reliance on CMOs for supply increases risk of delays, cost overruns, or quality issues impacting development efforts.
Outlook
Advance Bexobrutideg Registration Path Plan to leverage FDA Fast Track and EMA PRIME designations to accelerate registrational path for bexobrutideg in 2026.
Expand Therapeutic Applications Explore bexobrutideg utility in autoimmune and inflammatory diseases via separate clinical program requiring new IND filing.
Continue Pipeline Development Advance zelebrudomide dose escalation; define doses for NX-1607 Phase 1b cohort expansion in 2026.
Leverage DEL-AI Platform Continue investing in DEL-AI engine to support wholly owned pipeline and secure future strategic discovery partnerships.
Peer Comparison
Revenue (TTM)
$263.50M
$175.11M
$158.18M
Gross Margin (Latest Quarter)
215.9%
100.0%
97.3%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| ERAS | $4.54B | -33.2 | -34.5% | 11.9% |
| TERN | $4.36B | -47.0 | -30.0% | 0.3% |
| TNGX | $2.26B | -22.2 | -50.3% | 8.4% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-9.7%
Growth Under Pressure
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention
Deep Research
Next earnings:Apr 6, 2026
EPS:-
|Revenue:-
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement | LTM |
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