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Nurix Therapeutics, Inc.

NASDAQ•NRIX
CEO: Dr. Arthur T. Sands M.D., Ph.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2020-07-24
Nurix Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the discovery, development, and commercialization of small molecule and cell therapies for the treatment of cancer, inflammatory conditions, and other diseases. The company develops NX-2127, an orally bioavailable Bruton's tyrosine kinase (BTK) degrader for the treatment of relapsed or refractory B-cell malignancies; NX-5948, an orally bioavailable BTK degrader for the treatment of relapsed or refractory B-cell malignancies and autoimmune diseases; and NX-1607, an orally bioavailable Casitas B-lineage lymphoma proto-oncogene-B (CBL-B) inhibitor for immuno-oncology indications. It is also developing NX-0479/GS-6791, a IRAK4 degrader for the treatment of rheumatoid arthritis and other inflammatory diseases. The company has a strategic collaboration agreement with Gilead Sciences, Inc., Sanofi S.A., and Seagen Inc. co-development and co-commercialization for multiple drug candidates. The company was formerly known as Nurix Inc. and changed its name to Nurix Therapeutics, Inc. in October 2018. Nurix Therapeutics, Inc. was incorporated in 2009 and is headquartered in San Francisco, California.
Contact Information
1700 Owens Street, Suite 205, San Francisco, CA, 94158, United States
415-660-5320
www.nurixtx.com
Market Cap
$1.25B
P/E (TTM)
-5.2
17.7
Dividend Yield
--
52W High
$22.50
52W Low
$8.18
52W Range
44%
Rank52Top 73.5%
2.9
F-Score
Modified Piotroski Analysis
Based on 7-year fundamentals
Weak • 2.9 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2019-2025

Financial Dashboard

Q4 2025 Data

Revenue

$13.58M+2.21%
4-Quarter Trend

EPS

-$0.82+9.33%
4-Quarter Trend

FCF

-$72.96M+43.47%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Revenue Driven By License Deal Total revenue reached $84.0M, up $29.4M, driven by $30.0M license revenue recognized from Sanofi extensions.
Increased R&D Investment Research and development expenses totaled $316.9M, reflecting a $95.3M increase year-over-year to accelerate clinical trials.
Strong Liquidity Position Cash, cash equivalents, and marketable securities totaled $592.9M as of November 30, 2025, funding operations for 12 months.
Lead Drug Advancement Bexobrutideg Phase 2 enrollment ongoing; planning suite of additional trials for 2026 registration support.

Risk Factors

Continued Operating Losses Net loss was $(264.5M) for 2025; expects incurring losses for several future years, never achieving profitability.
Substantial Capital Needs Requires substantial additional funding to support operations; inability to raise capital may delay or terminate programs.
Early Stage Clinical Risk Lead candidates (bexobrutideg, zelebrudomide, NX-1607) are in early clinical stages; failure materially harms business.
Reliance on Third-Party Manufacturing Reliance on CMOs for supply increases risk of delays, cost overruns, or quality issues impacting development efforts.

Outlook

Advance Bexobrutideg Registration Path Plan to leverage FDA Fast Track and EMA PRIME designations to accelerate registrational path for bexobrutideg in 2026.
Expand Therapeutic Applications Explore bexobrutideg utility in autoimmune and inflammatory diseases via separate clinical program requiring new IND filing.
Continue Pipeline Development Advance zelebrudomide dose escalation; define doses for NX-1607 Phase 1b cohort expansion in 2026.
Leverage DEL-AI Platform Continue investing in DEL-AI engine to support wholly owned pipeline and secure future strategic discovery partnerships.

Peer Comparison

Revenue (TTM)

IOVA stock ticker logoIOVA
$263.50M
+60.6%
PHAT stock ticker logoPHAT
$175.11M
+216.9%
DAWN stock ticker logoDAWN
$158.18M
+20.6%

Gross Margin (Latest Quarter)

IOVA stock ticker logoIOVA
215.9%
+65.9pp
ABSI stock ticker logoABSI
100.0%
+197.2pp
KURA stock ticker logoKURA
97.3%
+0.0pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
ERAS$4.54B-33.2-34.5%11.9%
TERN$4.36B-47.0-30.0%0.3%
TNGX$2.26B-22.2-50.3%8.4%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-9.7%
Growth Under Pressure
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Deep Research

Next earnings:Apr 6, 2026
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LTM
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