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Heron Therapeutics, Inc.

NASDAQ•HRTX
CEO: Mr. Craig Alexander Collard
Sector: Healthcare
Industry: Biotechnology
Listing Date: 1987-08-26
Heron Therapeutics, Inc., a commercial-stage biotechnology company, focuses on enhancing the lives of patients by developing and commercializing therapeutic that enhances medical care. The company's product candidates utilize its proprietary Biochronomer, a drug delivery technology, which delivers therapeutic levels of a range of short-acting pharmacological agents over a period from days to weeks with a single administration. It offers SUSTOL (granisetron), an extended-release injection for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy, or anthracycline and cyclophosphamide combination chemotherapy regimens; and CINVANTI, an intravenous formulation of aprepitant, a substance P/neurokinin-1 receptor antagonist for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy, as well as nausea and vomiting associated with moderately emetogenic cancer chemotherapy. The company is also developing ZYNRELEF, a dual-acting local anesthetic that delivers a fixed-dose combination of the local anesthetic bupivacaine and a low dose of the nonsteroidal anti-inflammatory drug meloxicam; and APONVIE, an intravenous formulation of a substance P/neurokinin-1 receptor antagonist indicated for the prevention of postoperative nausea and vomiting in adults. The company was formerly known as A.P. Pharma, Inc. and changed its name to Heron Therapeutics, Inc. in January 2014. Heron Therapeutics, Inc. was founded in 1983 and is headquartered in Cary, North Carolina.
Contact Information
100 Regency Forest Drive, Suite 300, Cary, NC, 27518, United States
844-437-6611
www.herontx.com
Market Cap
$181.63M
P/E (TTM)
-9.5
19.9
Dividend Yield
--
52W High
$2.68
52W Low
$1.00
52W Range
9%
Rank68Top 98.2%
1.3
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 1.3 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025

Financial Dashboard

Q4 2025 Data

Revenue

$40.59M+0.00%
4-Quarter Trend

EPS

-$0.02+0.00%
4-Quarter Trend

FCF

-$9.18M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Net Sales Increased 7.4% Total net product sales reached $154.9M in 2025, driven by strong acute care performance and market share gains.
Operating Loss Significantly Narrows Loss from operations improved $9.0M to $2.5M in 2025, reflecting better cost control across R&D and G&A.
Acute Care Sales Skyrocket Acute care net product sales increased 65.1% to $49.6M, primarily driven by increased units sold for ZYNRELEF and APONVIE.
Equity Position Reverses Stockholders' equity improved $48.0M to $14.3M positive balance, successfully reversing the prior year's $33.7M deficit.

Risk Factors

Product Market Acceptance Risk Business substantially dependent on commercial success; failure to gain acceptance by professionals impacts operations and results.
Pricing and Reimbursement Pressure Unsatisfactory pricing or unfavorable reimbursement from government and third-party payors may severely limit product sales and future revenue.
Ongoing Patent Litigation Exposure Vigorously defending CINVANTI and APONVIE patents against multiple ANDA filers creates legal costs and uncertainty.
Oncology Sales Contraction Oncology net sales declined 7.8% due to gross-to-net adjustments and winding down SUSTOL commercialization efforts.

Outlook

SUSTOL Commercial Wind Down Intend to wind down SUSTOL commercialization over 12 months; evaluating potential product updates for late 2027 reintroduction.
ZYNRELEF Reimbursement Gains ZYNRELEF secured permanent J-code and NOPAIN policy inclusion, removing financial barriers for Medicare access starting 2025.
Cash Runway Secured Cash, equivalents, and investments total $46.6M, sufficient to meet anticipated cash requirements for at least one year.
Strategic Co-Promotion Focus Expanding ZYNRELEF orthopedic promotion via five-year co-promotion agreement with Crosslink Network initiated in January 2024.

Peer Comparison

Revenue (TTM)

HRTX stock ticker logoHRTX
$154.90M
+7.4%
GNFT stock ticker logoGNFT
$126.71M
+9.8%
CHRS stock ticker logoCHRS
$83.57M
-63.6%

Gross Margin (Latest Quarter)

GNFT stock ticker logoGNFT
100.0%
+0.0pp
SGMO stock ticker logoSGMO
100.0%
+0.0pp
IVVD stock ticker logoIVVD
91.7%
+0.4pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
SLS$756.37M-22.2-95.2%1.2%
GNFT$448.17M-10.9-63.7%64.1%
EPRX$268.51M-10.5-62.5%0.2%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
1.4%
Moderate Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
25%
Cash Flow Needs Attention

Deep Research

Next earnings:May 4, 2026
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