Gyre Therapeutics, Inc.
NASDAQ•GYRE
CEO: Dr. Han Ying Ph.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2006-04-12
Gyre Therapeutics, Inc., a pharmaceutical company, engages in the development and commercialization of small-molecule, anti-inflammatory, and anti-fibrotic drugs targeting organ fibrosis. It offers ETUARY (Pirfenidone), an anti-fibrotic drug approved for the treatment of idiopathic pulmonary fibrosis; and under phase 3 studies for dermatomyositis and systemic sclerosis-associated interstitial lung disease, pneumoconiosis, and diabetic kidney disease. The company is also involved the development of F351 (Hydronidone), a structural derivative of ETUARY (Pirfenidone), under Phase 3 studies for the treatment of chronic hepatitis B liver fibrosis; and under Phase 1 studies for liver fibrosis associated with nonalcoholic associated steatohepatitis. In addition, its development pipeline includes F573, under Phase 2 studies for the treatment of acute/acute-on-chronic liver failure; F528, under preclinical stage for the treatment of chronic obstructive pulmonary disease; and F230, under preclinical stage for the treatment of pulmonary arterial hypertension. The company was founded in 2002 and is headquartered in San Diego, California. Gyre Therapeutics, Inc. operates as a subsidiary of GNI USA, Inc.
Contact Information
Market Cap
$713.49M
P/E (TTM)
105.2
37
Dividend Yield
--
52W High
$13.75
52W Low
$6.11
52W Range
Rank53Top 76.1%
2.8
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 2.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025
Financial Dashboard
Q3 2025 Data
Revenue
$30.56M+19.91%
4-Quarter Trend
EPS
$0.27+362.33%
4-Quarter Trend
FCF
$3.99M+306.21%
4-Quarter Trend
2025 Q3 Earnings Highlights
Key Highlights
Revenue Growth Driven By Products Nine months 2025 Revenues reached $79.4M, up 2%, driven by $6.1M combined sales from Contiva® and Etorel®.
Strong Cash Position Maintained Cash and equivalents totaled $40.4M as of September 30, 2025; operations provided $6.6M cash flow for nine months.
Warrant Liability Impact Reduced Change in fair value of warrant liability decreased 65% to $2.4M gain for nine months ended September 30, 2025.
Common Stockholder Earnings Drop Net income attributable to common stockholders fell 45% to $6.8M for the nine months ended September 30, 2025.
Risk Factors
Profitability Declined Significantly Net income dropped 35% to $11.2M for nine months 2025, despite 2% revenue increase.
Core Product Sales Weakness ETUARY® revenue declined $4.4M for nine months 2025 due to marketing focus shift and market uncertainty.
High Customer Concentration Risk Sinopharm accounted for 50.3% of accounts receivable as of September 30, 2025, posing credit risk concentration.
Outlook
Hydronidone Trial Initiation Planned Anticipated initiation of the adaptive Phase 2/3 clinical trial for Hydronidone in the fourth quarter of 2025.
Etorel® Procurement Selection Etorel® selected in National Centralized Drug Procurement process; assessing potential impact on future operating performance.
R&D Investment Continues Committed $37.6M toward future R&D, including $12.9M for the Hydronidone program through September 30, 2025.
Peer Comparison
Revenue (TTM)
ARVN$312.30M
AKBA$225.07M
DAWN$133.67M
Gross Margin (Latest Quarter)
ARVN100.0%
94.7%
DAWN88.7%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| TERN | $3.09B | -33.3 | -30.0% | 0.3% |
| OLMA | $1.98B | -14.4 | -41.5% | 1.3% |
| TYRA | $1.62B | -16.2 | -35.8% | 2.0% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
3.1%
Moderate Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
50%
Cash Flow Needs Attention
Research & Insights
Next earnings:Mar 16, 2026
EPS:$0.08
|Revenue:-
Reports
All Years
Form 10-Q - Q3 2025
Period End: Sep 30, 2025|Filed: Nov 7, 2025|Revenue: $30.56M+19.9%|EPS: $0.27+362.3%MeetForm 10-Q - Q2 2025
Period End: Jun 30, 2025|Filed: Aug 11, 2025|Revenue: $26.77M+6.1%|EPS: $0.01-87.9%MissForm 10-Q - Q1 2025
Period End: Mar 31, 2025|Filed: May 9, 2025|Revenue: $22.06M-18.8%|EPS: $0.03-66.9%MissForm 10-K - FY 2024
Period End: Dec 31, 2024|Filed: Mar 17, 2025|Revenue: $105.76M-6.8%|EPS: $0.14+109.9%BeatForm 10-Q - Q3 2024
Period End: Sep 30, 2024|Filed: Nov 13, 2024|Revenue: $25.49M-20.5%|EPS: $0.06+12.5%N/AForm 10-Q - Q2 2024
Period End: Jun 30, 2024|Filed: Aug 13, 2024|Revenue: $25.23M-3.5%|EPS: $0.04-48.4%N/AForm 10-Q - Q1 2024
Period End: Mar 31, 2024|Filed: May 13, 2024|Revenue: $27.17M+11.2%|EPS: $0.09+17.8%N/AForm 10-K - FY 2023
Period End: Dec 31, 2023|Filed: Mar 27, 2024|Revenue: $113.45M+10.9%|EPS: $-1.41-4784.4%Miss