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Disc Medicine, Inc.

NASDAQ•IRON
CEO: Dr. Donald William Nicholson Ph.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2020-08-12
Disc Medicine, Inc., together with its subsidiaries, a clinical-stage biopharmaceutical company, engages in the discovery, development, and commercialization of novel treatments for patients suffering from serious hematologic diseases in the United States. The company has assembled a portfolio of clinical and preclinical product candidates that aim to modify fundamental biological pathways associated with the formation and function of red blood cells, primarily heme biosynthesis and iron homeostasis. Its pipeline includes bitopertin for the treatment of erythropoietic porphyrias, including erythropoietic protoporphyria, X-linked protoporphyria, and diamond-blackfan anemia; DISC-0974 for the treatment of anemia of myelofibrosis, and anemia of chronic kidney disease; and DISC-3405 for the treatment of polycythemia vera, and other hematologic disorders. The company's preclinical programs include DISC-0998, for the treatment of anemia associated with inflammatory diseases. Disc Medicine, Inc. was founded in 2017 and is headquartered in Watertown, Massachusetts.
Contact Information
321 Arsenal Street, Suite 101, Watertown, MA, 02472, United States
617-674-9274
www.discmedicine.com
Market Cap
$2.53B
P/E (TTM)
-11.0
17.5
Dividend Yield
--
52W High
$99.50
52W Low
$30.82
52W Range
51%
Rank59Top 87.6%
2.2
F-Score
Modified Piotroski Analysis
Based on 5-year fundamentals
Weak • 2.2 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2021-2025

Financial Dashboard

Q4 2025 Data

Revenue

$0.00+0.00%
4-Quarter Trend

EPS

-$1.64+0.00%
4-Quarter Trend

FCF

-$43.32M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

R&D Spending Surge Research spending reached $170.6M in 2025, marking a $74.0M increase over 2024 expenses.
Financing Activities Strong Secured $473.4M in net cash from financing activities during 2025, mainly through equity offerings.
Bitopertin NDA Submitted Submitted NDA for bitopertin accelerated approval in September 2025 for EPP and XLP indications.
Strong Cash Position Ended 2025 with $791.2M in cash, cash equivalents, and marketable securities to fund operations.

Risk Factors

Net Loss Widened Significantly Net loss reached $(212.2)M in 2025, nearly doubling from $(109.4)M reported in the prior year.
Bitopertin Regulatory Setback FDA issued a Complete Response Letter in February 2026 regarding bitopertin NDA submission.
No Product Sales Revenue Zero revenue generated from product sales; continued reliance on capital resources for future development.
High Operating Cash Burn Net cash used in operating activities totaled $(180.4)M for 2025, reflecting high pipeline investment.

Outlook

APOLLO Phase 3 Data Due Expect topline data from Phase 3 APOLLO trial in Q4 2026 to support potential traditional approval response.
DISC-0974 Data Expected Anticipate topline data for DISC-0974 in anemia of MF from RALLY-MF Phase 2 trial during 2026.
DISC-3405 Trial Updates Plan to report initial data from RESTORE-PV trial for DISC-3405 in PV during the second half of 2026.
FDA CRL Strategy Meeting Plan to request Type A meeting with FDA to review approach following the bitopertin Complete Response Letter.

Peer Comparison

Revenue (TTM)

LEGN stock ticker logoLEGN
$908.96M
+74.7%
TVTX stock ticker logoTVTX
$490.73M
+110.5%
ZLAB stock ticker logoZLAB
$460.16M
+15.3%

Gross Margin (Latest Quarter)

BEAM stock ticker logoBEAM
95.0%
-471.3pp
TARS stock ticker logoTARS
92.8%
-14.0pp
ARQT stock ticker logoARQT
91.0%
+3.5pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
IBRX$8.24B-22.664.3%175.0%
BLTE$6.53B-75.2-42.7%0.0%
CDTX$5.61B-18.6-60.1%0.4%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
N/M
Revenue Volatile
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Deep Research

Next earnings:May 5, 2026
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EPS:-
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Earnings Calls
Reports
News
Income Statement
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LTM
No Data