Entrada Therapeutics, Inc.
NASDAQ•TRDA
CEO: Mr. Dipal Doshi
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2021-10-29
Entrada Therapeutics, Inc., a clinical-stage biotechnology company, develops endosomal escape vehicle (EEV) therapeutics for the treatment of multiple neuromuscular diseases. Its EEV platform develops a portfolio of oligonucleotide, antibody, and enzyme-based programs. Its therapeutic candidates, which include ENTR-601-44, which is in Phase I clinical trial for the treatment of Duchenne muscular dystrophy; and ENTR-701, which is in Phase 1/2 clinical trial for the treatment of myotonic dystrophy type 1. The company also offers ENTR-601-45 and ENTR-601-50, which are in preclinical trail for the treatment of Duchenne muscular dystrophy; and ENTR-501, an intracellular thymidine phosphorylase enzyme replacement therapy, which is in preclinical trail for the treatment of mitochondrial neurogastrointestinal encephalomyopathy. Entrada Therapeutics, Inc. has a strategic collaboration and license agreement with Vertex Pharmaceuticals Incorporated to research, develop, manufacture, and commercialize ENTR-701. The company was formerly known as CycloPorters, Inc. and changed its name to Entrada Therapeutics, Inc. in October 2017. Entrada Therapeutics, Inc. was incorporated in 2016 and is headquartered in Boston, Massachusetts.
Contact Information
One Design Center Place, Suite 17- 500, Boston, MA, 02210, United States
857-520-9158
Market Cap
$456.73M
P/E (TTM)
-3.4
17.7
Dividend Yield
--
52W High
$13.66
52W Low
$4.93
52W Range
Rank43Top 50.7%
3.8
F-Score
Modified Piotroski Analysis
Based on 6-year fundamentals
Weak • 3.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2020-2025
Financial Dashboard
Q4 2025 Data
Revenue
$1.30M+0.00%
4-Quarter Trend
EPS
-$0.95+0.00%
4-Quarter Trend
FCF
-$32.00M+0.00%
4-Quarter Trend
2025 Annual Earnings Highlights
Key Highlights
R&D Spending Ramps Up Total R&D expenses rose $17.0M to $142.3M in 2025, supporting advancement of DMD and ocular programs.
Collaboration Revenue Declines Collaboration revenue fell $185.4M to $25.4M in 2025, primarily due to substantial completion of VX-670 research plan activities.
Substantial Accumulated Deficit Accumulated deficit reached $(273.1)M as of December 31, 2025, reflecting capital-intensive development stage operations.
Cash Position Maintained Cash, cash equivalents, and restricted cash totaled $94.3M at year-end 2025, supporting operations into Q3 2027.
Risk Factors
Financing Needs Remain High Requires substantial additional financing to achieve goals; failure to secure capital could delay or terminate development programs.
Clinical Success Highly Uncertain Business highly dependent on clinical advancement of lead candidates ENTR-601-44, -45, -50, -51, and VX-670 success.
Novel Platform Unproven Risk EEV Platform approach is unproven; unable to predict development costs or regulatory approval timeline for candidates.
Intense Competition Threatens Success Faces significant competition in DMD space; competitors developing more rapid or effective therapeutic candidates.
Outlook
Key 2026 Pipeline Progress Expect progress on ENTR-601-44/45 trials, EU filing for ENTR-601-50, and regulatory submissions for ENTR-601-51 during 2026.
VX-670 Dosing Completion Vertex partnership VX-670 dosing completion anticipated mid-2026; reporting patient data from two ENTR-601 cohorts during 2026.
Cash Runway Extended Current cash sufficient to fund operations into the third quarter of 2027 based on current operating plans and estimates.
Expanding Ocular Preclinical Pipeline Plans to announce second ocular clinical candidate in H2 2026, advancing portfolio diversification beyond neuromuscular focus.
Peer Comparison
Revenue (TTM)
$216.11M
$74.12M
$66.98M
Gross Margin (Latest Quarter)
103.9%
100.0%
100.0%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| CAPR | $1.32B | -13.4 | -67.5% | 5.9% |
| ALLO | $550.94M | -2.6 | -57.1% | 20.0% |
| TRDA | $456.73M | -3.4 | -39.8% | 13.5% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-60.2%
Growth Under Pressure
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention
Deep Research
Next earnings:May 6, 2026
EPS:-
|Revenue:-
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement | LTM |
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No Data