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Entrada Therapeutics, Inc.

Entrada Therapeutics, Inc.

NASDAQ•TRDA
CEO: Mr. Dipal Doshi
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2021-10-29
Entrada Therapeutics, Inc., a clinical-stage biotechnology company, develops endosomal escape vehicle (EEV) therapeutics for the treatment of multiple neuromuscular diseases. Its EEV platform develops a portfolio of oligonucleotide, antibody, and enzyme-based programs. Its therapeutic candidates, which include ENTR-601-44, which is in Phase I clinical trial for the treatment of Duchenne muscular dystrophy; and ENTR-701, which is in Phase 1/2 clinical trial for the treatment of myotonic dystrophy type 1. The company also offers ENTR-601-45 and ENTR-601-50, which are in preclinical trail for the treatment of Duchenne muscular dystrophy; and ENTR-501, an intracellular thymidine phosphorylase enzyme replacement therapy, which is in preclinical trail for the treatment of mitochondrial neurogastrointestinal encephalomyopathy. Entrada Therapeutics, Inc. has a strategic collaboration and license agreement with Vertex Pharmaceuticals Incorporated to research, develop, manufacture, and commercialize ENTR-701. The company was formerly known as CycloPorters, Inc. and changed its name to Entrada Therapeutics, Inc. in October 2017. Entrada Therapeutics, Inc. was incorporated in 2016 and is headquartered in Boston, Massachusetts.
Contact Information
One Design Center Place, Suite 17- 500, Boston, MA, 02210, United States
857-520-9158
www.entradatx.com
Market Cap
$397.86M
P/E (TTM)
-4.2
40.5
Dividend Yield
--
52W High
$18.76
52W Low
$4.93
52W Range
40%
Rank45Top 43.2%
4.0
F-Score
Modified Piotroski Analysis
Based on 6-year fundamentals
Average • 4 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2019-2024

Financial Dashboard

Q3 2025 Data

Revenue

$1.61M-91.75%
4-Quarter Trend

EPS

-$1.06+202.86%
4-Quarter Trend

FCF

-$28.14M+13.00%
4-Quarter Trend

2025 Q3 Earnings Highlights

Key Highlights

Collaboration Revenue Drops Sharply Collaboration revenue $24.1M for nine months, down $149.3M. Decrease driven by substantial completion of VX-670 research plan activities.
Nine Months Net Loss Recorded Nine months net loss $(104.6M), reversing $64.5M net income last year. Operating expenses rose to $139.8M.
DMD Pipeline Advances Clinically R&D expenses increased $16.4M to $108.3M for nine months. Focus remains on advancing DMD candidates ENTR-601-44 and -45.
Cash Runway Extended to 2027 Cash, cash equivalents, and marketable securities total $326.8M. Sufficient to fund operations into third quarter of 2027.

Risk Factors

High Cash Burn Rate Net cash used in operating activities reached $(96.3M) for nine months. Requires substantial additional financing to support operations.
Development Success Highly Uncertain Business highly dependent on clinical advancement of lead candidates like ENTR-601-44. Novel EEV approach success remains uncertain.
Limited Operating History Risks Company has limited operating history, incurred significant losses, and expects continued losses for foreseeable future.
Intense Competitive Landscape Faces significant competition in DMD space from approved products and advanced pipeline candidates from larger firms.

Outlook

ENTR-601-44 Data Expected Expect reporting data from ENTR-601-44 Phase 1/2 Cohort 1 during second quarter of 2026.
New Regulatory Filings Planned Planning EU regulatory clearance submission for ENTR-601-50 in second half of 2026; filing for ENTR-601-51 in 2026.
Ocular Franchise Expansion Anticipate sharing first clinical candidate in ocular disease later in 2025, complementing existing neuromuscular focus.
Vertex Partnership Progress Vertex VX-670 trial on track to complete enrollment and dosing in the first half of 2026.

Peer Comparison

Revenue (TTM)

Enanta Pharmaceuticals, Inc.ENTA
$65.32M
-3.4%
Entrada Therapeutics, Inc.TRDA
$61.52M
-71.4%
Sangamo Therapeutics, Inc.SGMO
$32.88M
-37.1%

Gross Margin (Latest Quarter)

Sangamo Therapeutics, Inc.SGMO
100.0%
+6804.2pp
OmniAb, Inc.OABI
98.7%
-1.3pp
Foghorn Therapeutics Inc.FHTX
88.1%
-11.9pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
TRDA$397.86M-4.2-26.4%12.7%
ENTA$359.47M-4.4-93.8%71.6%
FHTX$305.36M-4.5142.2%10.5%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
-64.9%
Growth Under Pressure
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Research & Insights

Next earnings:Feb 26, 2026
|
EPS:-$1.06
|
Revenue:-
Reports
All Years
  • Form 10-Q - Q3 2025

    Period End: Sep 30, 2025|Filed: Nov 6, 2025|
    Revenue: $1.61M-91.8%
    |
    EPS: $-1.06+202.9%
    Miss
  • Form 10-Q - Q2 2025

    Period End: Jun 30, 2025|Filed: Aug 6, 2025|
    Revenue: $1.95M-97.9%
    |
    EPS: $-1.04-164.6%
    Miss
  • Form 10-Q - Q1 2025

    Period End: Mar 31, 2025|Filed: May 8, 2025|
    Revenue: $20.56M-65.2%
    |
    EPS: $-0.42-160.0%
    Beat
  • Form 10-K - FY 2024

    Period End: Dec 31, 2024|Filed: Feb 27, 2025|
    Revenue: $210.78M+63.4%
    |
    EPS: $1.76+980.0%
    Beat
  • Form 10-Q - Q3 2024

    Period End: Sep 30, 2024|Filed: Nov 5, 2024|
    Revenue: $19.57M-55.3%
    |
    EPS: $-0.35-132.7%
    Beat
  • Form 10-Q - Q2 2024

    Period End: Jun 30, 2024|Filed: Aug 13, 2024|
    Revenue: $94.69M+421.2%
    |
    EPS: $1.61-306.4%
    Beat
  • Form 10-Q - Q1 2024

    Period End: Mar 31, 2024|Filed: May 7, 2024|
    Revenue: $59.12M+134.0%
    |
    EPS: $0.70-433.3%
    Beat
  • Form 10-K - FY 2023

    Period End: Dec 31, 2023|Filed: Mar 13, 2024|
    Revenue: $129.01M+0.0%
    |
    EPS: $-0.20+92.8%
    Miss