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Rhythm Pharmaceuticals, Inc.

NASDAQ•RYTM
CEO: Dr. David P. Meeker M.D.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2017-10-09
Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is in Phase 3 clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, and other MC4R disorders. The company has licensing agreements with LG Chem, Ltd; Ipsen Pharma S.A.S; Camurus; RareStone Group Ltd.; joint research collaboration with Axovia Therapeutics for developing in bardet-biedl syndrome; and LG Chem, Ltd. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
Contact Information
222 Berkeley Street, 12th Floor, Boston, MA, 02116, United States
857-264-4280
rhythmtx.com
Market Cap
$5.98B
P/E (TTM)
-30.5
19.9
Dividend Yield
--
52W High
$122.20
52W Low
$45.91
52W Range
57%
Rank63Top 94.0%
1.8
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 1.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025

Financial Dashboard

Q4 2025 Data

Revenue

$57.25M+0.00%
4-Quarter Trend

EPS

-$0.73+0.00%
4-Quarter Trend

FCF

-$26.34M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Strong Product Revenue Growth Product revenue reached $194.8M USD in 2025, marking a 50% increase over 2024 sales figures.
R&D Spending Decreased Research and development expenses fell $70.6M USD, down 30% from 2024, due to IPR&D cost non-recurrence.
Operating Loss Significantly Reduced Loss from operations improved $73.5M USD, down 28% to a $192.0M USD loss for 2025.
Pipeline Advancement Milestones Setmelanotide AHO PDUFA date set for March 20, 2026; EMANATE Phase 3 data expected early 2026.

Risk Factors

Limited Operating History Risks Commercial stage company anticipates continued losses; profitability remains uncertain despite $422.5M lifetime product sales.
Capital Raising Uncertainty Additional funding required; failure to secure necessary capital may delay or terminate product development efforts.
Reimbursement Coverage Limits Revenue IMCIVREE commercial success depends on payor coverage; failure to secure reimbursement severely limits revenue generation potential.
Early Trial Results Not Predictive Positive results from early setmelanotide trials may not predict later trial outcomes or regulatory success for new indications.

Outlook

Acquired HO Market Launch Anticipate launching IMCIVREE for acquired hypothalamic obesity in US during 2026, pending regulatory approval.
Bivamelagon Phase 3 Planning Plan to initiate Phase 3 registrational trial for bivamelagon in acquired hypothalamic obesity by year-end 2026.
CHI Candidate Nomination Focused on identifying and nominating a development candidate for Congenital Hyperinsulinism (CHI) program in 2026.
Japan Regulatory Submissions Expect to complete new drug application submission in Japan pending positive Phase 3 Japanese cohort data in March 2026.

Peer Comparison

Revenue (TTM)

KNSA stock ticker logoKNSA
$677.56M
+60.1%
ARVN stock ticker logoARVN
$262.60M
-0.3%
STOK stock ticker logoSTOK
$205.63M
+1128.2%

Gross Margin (Latest Quarter)

SNDX stock ticker logoSNDX
102.3%
-13.9pp
PTGX stock ticker logoPTGX
94.9%
+0.0pp
QURE stock ticker logoQURE
92.2%
+33.9pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
RVMD$19.43B-16.9-63.1%6.7%
NUVL$7.29B-17.7-42.1%0.0%
ACLX$6.59B-28.1-55.4%15.9%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
20.5%
Strong Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Deep Research

Next earnings:May 5, 2026
|
EPS:-$0.78
|
Revenue:$58.03M
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement
LTM
No Data