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Vaxcyte, Inc.

NASDAQ•PCVX
CEO: Mr. Grant E. Pickering M.B.A.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2020-06-12
Vaxcyte, Inc., a clinical-stage biotechnology vaccine company, develops novel protein vaccines to prevent or treat bacterial infectious diseases. Its lead vaccine candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine for the prevention of invasive pneumococcal disease. The company also develops VAX-31 to protect against emerging strains and to help address antibiotic resistance; VAX-A1, a novel conjugate vaccine candidate to prevent disease caused by Group A Streptococcus; VAX-PG, a novel protein vaccine candidate targeting keystone pathogen responsible for periodontitis; and VAX-GI to prevent Shigella, a bacterial illness. The company was formerly known as SutroVax, Inc. and changed its name to Vaxcyte, Inc. in May 2020. Vaxcyte, Inc. was incorporated in 2013 and is headquartered in San Carlos, California.
Contact Information
825 Industrial Road, Suite 300, San Carlos, CA, 94070, United States
650-837-0111
vaxcyte.com
Market Cap
$8.73B
P/E (TTM)
-10.8
18.5
Dividend Yield
--
52W High
$65.00
52W Low
$27.66
52W Range
88%
Rank63Top 94.0%
1.8
F-Score
Modified Piotroski Analysis
Based on 8-year fundamentals
Weak • 1.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2018-2025

Financial Dashboard

Q4 2025 Data

Revenue

$0.00+0.00%
4-Quarter Trend

EPS

-$1.81+0.00%
4-Quarter Trend

FCF

-$219.26M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

R&D Spending Ramps Up Research and development expenses increased 66.6% to $794.3M in 2025, driven by adult and infant PCV programs.
Strong Liquidity Position Maintained Cash and investments totaled $2.44B as of December 31, 2025, funding operations well into 2026.
VAX-31 Adult Phase 3 Initiated Pivotal OPUS-1 trial for VAX-31 adult indication commenced in December 2025 against PCV21/PCV20.
Significant Equity Financing Closed Completed February 2026 underwritten offering, raising gross proceeds of $632.5M before expenses.

Risk Factors

Continued Substantial Net Losses Net loss widened to $766.6M in 2025; company anticipates increasing operating losses for several future years.
High Capital Requirements Remain Substantial additional funding is required to complete development, manufacturing, and commercialization efforts.
Reliance on Third-Party Manufacturing Business highly dependent on CMOs like Lonza for supply; disruptions could materially affect development timelines.
Stock Price Volatility Risk Common stock price remains highly volatile, subject to fluctuations beyond operating performance, causing investor risk.

Outlook

VAX-31 Pivotal Data Expected Topline safety and immunogenicity data from adult Phase 3 OPUS-1 trial anticipated in the fourth quarter of 2026.
Advance Novel Pipeline Candidates Plan to initiate Phase 1 adult study for VAX-A1 (Group A Strep) in 2026, leveraging site-specific conjugation.
Infant PCV Phase 3 Planning Phase 3 program for Optimized Dose VAX-24 or VAX-31 infants planned pending VAX-31 infant Phase 2 readout.
Long-Term Manufacturing Commitment Secured long-term U.S. commercial fill-finish capacity via a new agreement representing up to $1B commitment.

Peer Comparison

Revenue (TTM)

PTCT stock ticker logoPTCT
$1.73B
+114.5%
ALKS stock ticker logoALKS
$1.48B
-5.2%
ARWR stock ticker logoARWR
$1.09B
+4081.8%

Gross Margin (Latest Quarter)

CRNX stock ticker logoCRNX
111.8%
+0.0pp
RNA stock ticker logoRNA
100.0%
+0.0pp
ARWR stock ticker logoARWR
97.6%
+50.6pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
PCVX$8.73B-10.8-25.9%7.5%
AXSM$8.63B-46.6-254.1%35.0%
ARWR$8.57B42.436.1%19.5%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
N/M
Revenue Volatile
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention

Deep Research

Next earnings:May 5, 2026
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News
Income Statement
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LTM
No Data