Vaxcyte, Inc.
NASDAQ•PCVX
CEO: Mr. Grant E. Pickering M.B.A.
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2020-06-12
Vaxcyte, Inc., a clinical-stage biotechnology vaccine company, develops novel protein vaccines to prevent or treat bacterial infectious diseases. Its lead vaccine candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine for the prevention of invasive pneumococcal disease. The company also develops VAX-31 to protect against emerging strains and to help address antibiotic resistance; VAX-A1, a novel conjugate vaccine candidate to prevent disease caused by Group A Streptococcus; VAX-PG, a novel protein vaccine candidate targeting keystone pathogen responsible for periodontitis; and VAX-GI to prevent Shigella, a bacterial illness. The company was formerly known as SutroVax, Inc. and changed its name to Vaxcyte, Inc. in May 2020. Vaxcyte, Inc. was incorporated in 2013 and is headquartered in San Carlos, California.
Contact Information
Market Cap
$8.73B
P/E (TTM)
-10.8
18.5
Dividend Yield
--
52W High
$65.00
52W Low
$27.66
52W Range
Rank63Top 94.0%
1.8
F-Score
Modified Piotroski Analysis
Based on 8-year fundamentals
Weak • 1.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2018-2025
Financial Dashboard
Q4 2025 Data
Revenue
$0.00+0.00%
4-Quarter Trend
EPS
-$1.81+0.00%
4-Quarter Trend
FCF
-$219.26M+0.00%
4-Quarter Trend
2025 Annual Earnings Highlights
Key Highlights
R&D Spending Ramps Up Research and development expenses increased 66.6% to $794.3M in 2025, driven by adult and infant PCV programs.
Strong Liquidity Position Maintained Cash and investments totaled $2.44B as of December 31, 2025, funding operations well into 2026.
VAX-31 Adult Phase 3 Initiated Pivotal OPUS-1 trial for VAX-31 adult indication commenced in December 2025 against PCV21/PCV20.
Significant Equity Financing Closed Completed February 2026 underwritten offering, raising gross proceeds of $632.5M before expenses.
Risk Factors
Continued Substantial Net Losses Net loss widened to $766.6M in 2025; company anticipates increasing operating losses for several future years.
High Capital Requirements Remain Substantial additional funding is required to complete development, manufacturing, and commercialization efforts.
Reliance on Third-Party Manufacturing Business highly dependent on CMOs like Lonza for supply; disruptions could materially affect development timelines.
Stock Price Volatility Risk Common stock price remains highly volatile, subject to fluctuations beyond operating performance, causing investor risk.
Outlook
VAX-31 Pivotal Data Expected Topline safety and immunogenicity data from adult Phase 3 OPUS-1 trial anticipated in the fourth quarter of 2026.
Advance Novel Pipeline Candidates Plan to initiate Phase 1 adult study for VAX-A1 (Group A Strep) in 2026, leveraging site-specific conjugation.
Infant PCV Phase 3 Planning Phase 3 program for Optimized Dose VAX-24 or VAX-31 infants planned pending VAX-31 infant Phase 2 readout.
Long-Term Manufacturing Commitment Secured long-term U.S. commercial fill-finish capacity via a new agreement representing up to $1B commitment.
Peer Comparison
Revenue (TTM)
$1.73B
$1.48B
$1.09B
Gross Margin (Latest Quarter)
111.8%
100.0%
97.6%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| PCVX | $8.73B | -10.8 | -25.9% | 7.5% |
| AXSM | $8.63B | -46.6 | -254.1% | 35.0% |
| ARWR | $8.57B | 42.4 | 36.1% | 19.5% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
N/M
Revenue Volatile
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
0%
Cash Flow Needs Attention
Deep Research
Next earnings:May 5, 2026
EPS:-
|Revenue:-
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement | LTM |
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No Data