
Zevra Therapeutics, Inc.
NASDAQ•ZVRA
CEO: Mr. Neil F. McFarlane
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2015-04-16
Zevra Therapeutics, Inc. discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company develops its products through Ligand Activated Therapy platform. Its lead product candidate is KP1077, consisting of KP1077IH, which is under Phase 2 clinical trial for the treatment of idiopathic hypersomnia, and KP1077N, which is under Phase ½ clinical trial to treat narcolepsy. The company is also developing Celiprolol, a prodrug product candidate that is under Phase 1/2 clinical trial for the treatment of vascular Ehlers Danlos syndrome. In addition, it offers AZSTARYS, a once-daily treatment for attention deficit hyperactivity disorder in patients aged six years and older; OLPRUVA to treat urea cycle disorders; and Arimoclomol for the treatment of niemann pick disease type C, an ultra-rare neurodegenerative lysosomal storage disorder. The company has collaboration and license agreement with Commave Therapeutics SA to develop, manufacture and commercialize the company's product candidates containing SDX and d-methylphenidate; and license agreement with Acer and Relief Therapeutics, Inc. to develop and commercialize rights for OLPRUVA. The company was formerly known as KemPharm, Inc. and changed its name to Zevra Therapeutics, Inc. in February 2023. Zevra Therapeutics, Inc. was incorporated in 2006 and is headquartered in Celebration, Florida.
Contact Information
Market Cap
$499.90M
P/E (TTM)
184.0
45.9
Dividend Yield
--
52W High
$13.16
52W Low
$6.19
52W Range
0.6
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 0.6 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2015-2024
Financial Dashboard
Q3 2025 Data
Revenue
$26.06M+605.36%
4-Quarter Trend
EPS
-$0.01-98.59%
4-Quarter Trend
FCF
$4.16M-122.90%
4-Quarter Trend
2025 Q3 Earnings Highlights
Key Highlights
Nine Month Net Income Swing Net income $71.1M (9M 2025) versus $69.8M loss (2024). $140.8M swing driven by $148.3M gain on PRV sale.
Revenue Driven by MIPLYFFA Nine-month revenue reached $72.3M, up $60.8M. Increase primarily due to $61.0M in MIPLYFFA product sales.
Strong Cash Position Cash, equivalents, and investments total $230.4M as of September 30, 2025. Sufficient funding for next twelve months.
Equity Significantly Improved Total stockholders' equity increased to $133.2M from $39.7M. Reflects strong net income performance this reporting period.
Risk Factors
OLPRUVA Asset Impairment Recorded $58.7M impairment charge on OLPRUVA asset group in nine months 2025 due to unrecoverable future cash flows.
AZSTARYS License Litigation Ongoing legal dispute with Commave regarding license agreement interpretation. Outcome uncertain; significant legal expenses expected.
Future Funding Requirements Expect recurring negative operating cash flows; future capital raises may be necessary, potentially diluting existing stockholders.
Healthcare Regulatory Uncertainty Ongoing legislative changes regarding drug pricing and reimbursement could negatively impact future profitability and sales.
Outlook
MIPLYFFA European Approval Marketing Authorisation Application (MAA) submitted to EMA in July 2025 for European regulatory approval process.
KP1077 Strategic Review Phase 2 clinical trial for IH concluded; seeking strategic alternatives for development, potentially impacting future R&D spend.
Celiprolol VEDS Trial Progress Phase 3 DiSCOVER trial for VEDS restarted mid-2024; currently has 44 enrolled participants as of September 30, 2025.
R&D Spending Decreased R&D expenses decreased $23.6M (9M 2025) due to KP1077 Phase 2 completion and associated personnel cost reductions.
Peer Comparison
Revenue (TTM)
RGNX$161.32M
ARCT$95.83M
ZVRA$84.39M
Gross Margin (Latest Quarter)
RGNX80.7%
KALV58.6%
ZVRA52.2%
Key Metrics
Symbol | Market Cap | P/E (TTM) | ROE (TTM) | Debt to Assets |
|---|---|---|---|---|
| SVRA | $874.91M | -8.4 | -69.1% | 18.1% |
| MLTX | $813.45M | -4.6 | -41.6% | 16.5% |
| ATXS | $717.56M | -6.2 | -38.6% | 1.7% |
Long-Term Trends
Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
+29.3%
Strong Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
25%
Cash Flow Needs Attention
Research & Insights
Reports
All Years
Form 10-Q - Q3 2025
Period End: Sep 30, 2025|Filed: Nov 5, 2025|Revenue: $26.06M+605.4%|EPS: $-0.01-98.6%BeatForm 10-Q - Q2 2025
Period End: Jun 30, 2025|Filed: Aug 12, 2025|Revenue: $25.88M+481.7%|EPS: $1.36-383.3%MissForm 10-Q - Q1 2025
Period End: Mar 31, 2025|Filed: May 13, 2025|Revenue: $20.40M+495.7%|EPS: $-0.06-85.7%BeatForm 10-K - FY 2024
Period End: Dec 31, 2024|Filed: Mar 12, 2025|Revenue: $23.61M-14.0%|EPS: $-2.28-75.4%MissForm 10-Q - Q3 2024
Period End: Sep 30, 2024|Filed: Nov 13, 2024|Revenue: $3.70M+27.6%|EPS: $-0.69+130.0%MissForm 10-Q - Q2 2024
Period End: Jun 30, 2024|Filed: Aug 14, 2024|Revenue: $4.45M-47.5%|EPS: $-0.48+220.0%MissForm 10-Q - Q1 2024
Period End: Mar 31, 2024|Filed: May 9, 2024|Revenue: $3.43M+19.0%|EPS: $-0.40+17.6%MeetForm 10-K - FY 2023
Period End: Dec 31, 2023|Filed: Apr 1, 2024|Revenue: $27.46M+170.3%|EPS: $-1.30-66.7%Miss