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Zevra Therapeutics, Inc.

NASDAQ•ZVRA
CEO: Mr. Neil F. McFarlane
Sector: Healthcare
Industry: Biotechnology
Listing Date: 2015-04-16
Zevra Therapeutics, Inc. discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company develops its products through Ligand Activated Therapy platform. Its lead product candidate is KP1077, consisting of KP1077IH, which is under Phase 2 clinical trial for the treatment of idiopathic hypersomnia, and KP1077N, which is under Phase ½ clinical trial to treat narcolepsy. The company is also developing Celiprolol, a prodrug product candidate that is under Phase 1/2 clinical trial for the treatment of vascular Ehlers Danlos syndrome. In addition, it offers AZSTARYS, a once-daily treatment for attention deficit hyperactivity disorder in patients aged six years and older; OLPRUVA to treat urea cycle disorders; and Arimoclomol for the treatment of niemann pick disease type C, an ultra-rare neurodegenerative lysosomal storage disorder. The company has collaboration and license agreement with Commave Therapeutics SA to develop, manufacture and commercialize the company's product candidates containing SDX and d-methylphenidate; and license agreement with Acer and Relief Therapeutics, Inc. to develop and commercialize rights for OLPRUVA. The company was formerly known as KemPharm, Inc. and changed its name to Zevra Therapeutics, Inc. in February 2023. Zevra Therapeutics, Inc. was incorporated in 2006 and is headquartered in Celebration, Florida.
Contact Information
1180 Celebration Boulevard, Suite 103, Celebration, FL, 34747, United States
321-939-3416
zevra.com
Market Cap
$570.68M
P/E (TTM)
6.5
19
Dividend Yield
--
52W High
$13.16
52W Low
$6.77
52W Range
46%
Rank73Top 99.9%
0.8
F-Score
Modified Piotroski Analysis
Based on 10-year fundamentals
Weak • 0.8 / 9 points
Scoring Range (0-9)
8-9: Excellent Value
6-7: Strong Fundamentals
4-5: Average Quality
0-3: Weak Performance
Data Period: 2016-2025

Financial Dashboard

Q4 2025 Data

Revenue

$34.13M+0.00%
4-Quarter Trend

EPS

$0.21+0.00%
4-Quarter Trend

FCF

$5.55M+0.00%
4-Quarter Trend

2025 Annual Earnings Highlights

Key Highlights

Net Income Swing Positive Net income $83.2M 2025 vs $(105.5M) loss 2024; driven by $148.3M PRV sale gain.
Product Revenue Increased Substantially Net revenue $106.5M 2025, up $82.9M; MIPLYFFA sales contributed $87.4M to growth.
Operating Cash Flow Usage Reduced Operating cash used $(1.6M)$ 2025, significant improvement from $(69.7M)$ used in 2024.
R&D Spending Decreased Sharply R&D expenses dropped $29.4M to $12.7M in 2025, driven by KP1077 Phase 2 conclusion.

Risk Factors

Intangible Asset Impairment Recorded Recognized $58.7M impairment charge on intangible assets in Q2 2025; future asset impairment risks remain.
High Dependence on MIPLYFFA Highly dependent on MIPLYFFA for 82% of 2025 revenues; modest market changes disproportionately affect results.
Recurring Negative Cash Flows History of negative net operating cash flows; cannot guarantee consistent positive cash flow generation moving forward.
AZSTARYS Litigation Uncertainty AZSTARYS dispute with Commave ongoing; uncertain outcome may materially affect relationship and operations.

Outlook

Advancing Celiprolol VEDS Candidate Actively enrolling Phase 3 DiSCOVER trial for celiprolol in VEDS; seeking regulatory options to accelerate development.
Focus on Commercial Capabilities Expect substantial fluctuation in expenses continuing to build commercial capabilities for MIPLYFFA and OLPRUVA.
Evaluating OLPRUVA Strategic Alternatives Scaling back OLPRUVA sales/marketing efforts while evaluating path forward and weighing strategic alternatives.
Sufficient Liquidity Forecasted Available cash, cash flow, and borrowings sufficient to fund existing plans for at least next twelve months.

Peer Comparison

Revenue (TTM)

RIGL stock ticker logoRIGL
$294.28M
+64.1%
AKBA stock ticker logoAKBA
$236.19M
+47.5%
RGNX stock ticker logoRGNX
$170.44M
+104.5%

Gross Margin (Latest Quarter)

ATXS stock ticker logoATXS
100.0%
+0.0pp
MGTX stock ticker logoMGTX
99.4%
+33.5pp
GOSS stock ticker logoGOSS
98.4%
+0.0pp

Key Metrics

Symbol
Market Cap
P/E (TTM)
ROE (TTM)
Debt to Assets
OLMA$1.39B-9.0-42.9%0.2%
MLTX$1.32B-5.2-67.1%17.8%
CRVS$1.27B-78.4-23.3%1.3%

Long-Term Trends

Last 4 Quarters
Revenue
Net Income
Operating Cash Flow
4Q Revenue CAGR
18.7%
Strong Growth
4Q Net Income CAGR
N/M
Profitability Shift
Cash Flow Stability
50%
Cash Flow Needs Attention

Deep Research

Next earnings:May 7, 2026
|
EPS:$0.10
|
Revenue:$32.26M
Financials
Earnings Calls
Reports
News
Income Statement
Balance Sheet
Cash Flow Statement
Ratios
% Chg.
Income Statement
LTM
No Data